Skip to main contentSkip to main content
You have permission to edit this article.

49ers vs. Cardinals: FrontPageBets looks at best bets for Monday Night Football

  • Updated
  • 0
Chargers 49ers Football

San Francisco quarterback Jimmy Garoppolo and the 49ers are 8-point favorites against the Arizona Cardinals on Monday night in Mexico City.

Minnesota is the top team in the NFC entering Week 11, having won seven in a row by 8 points or less. In our game of the week, Kirk Cousins and the Vikings host the Dallas Cowboys. Watch now for all our picks and predictions.

Week 11 of the NFL season wraps up Monday night with an NFC West matchup between the San Francisco 49ers and the Arizona Cardinals in Mexico City.

Both teams are trying to keep pace in the division as they trail the surprise Seattle Seahawks.

The 49ers are 5-4 and have won their last two games, while the Cardinals are 4-6 and coming off a big win over the divisional rival Los Angeles Rams.

San Francisco is an 8-point favorite heading into Monday night's game at Estadio Azteca. The 49ers are 4-5 against the spread and 3-4 as a favorite. Arizona is 5-5 against the spread, including 4-3 as the underdog.

FrontPageBets takes a look at three best bets for this Monday Night Football game.

(Odds courtesy of DraftKings and subject to change.)

49ers RB Christian McCaffrey anytime touchdown (-140)

Christian McCaffrey has made his presence felt in San Francisco since arriving a month ago from the Carolina Panthers.

In his first three games as a 49er, McCaffery has 288 combined total rushing and receiving yards, averaging about 96 total yards per game. He's also scored three touchdowns, two rushing and one receiving. Oh, and he also threw a touchdown pass.

It's his versatility as a runner and receiver that makes him a threat to score from anywhere on the field.

Also, McCaffery has already faced the Cardinals this season on Oct. 2 with the Panthers, where he had a huge receiving day, catching nine passes for 81 yards and a touchdown.

49ers QB Jimmy Garoppolo over 0.5 interceptions (+115)

Quarterback Jimmy Garoppolo has been good with the ball all year, throwing only four interceptions in nine games.

However, the Cardinals defense is very opportunistic with seven INTs on the year and a plus-5 turnover margin. The 49ers are minus-3 in turnover margin.

Three of Garoppolo's four picks have come away from his home stadium.

Under 43.5 point total (-110)

If 44 or more points are scored in Monday night's game, it would be just the fourth time this season that mark has been hit this season on MNF.

In fact, five out of the first six Monday Night Football games didn't get out of the 30s in point totals, including a 24-9 49ers win over the Rams in Week 4.

San Francisco hasn't hit the over in any of their three prime-time games this season, while Arizona did it once.

Combined, these teams' Over/Under record is 8-10-1.

San Francisco 49ers vs. Arizona Cardinals

  • When: 8:15 p.m., ESPN
  • Spread: 49ers -8 (-110); Cardinals +8 (-110)
  • Money line: 49ers -350; Cardinals +290
  • Over/Under: 43.5 (-110)
  • The pick: 49ers, 24-17

Gambling problem? There is help. Call 1-800-522-4700 or visit the National Council on Problem Gambling for help.

Mike Szvetitz is the General Manager and Content Director for Szvetitz is a 22-year veteran reporter and editor, including serving 17 years as a sports editor in Florida, Alabama and Virginia, covering everything from preps to pros. His "View From The Lazy Boy" column won multiple state and national awards. He can be reached at

* I understand and agree that registration on or use of this site constitutes agreement to its user agreement and privacy policy.

Related to this story

Most Popular

Recommended for you