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Packers vs. Bills prediction, odds and pick for NFL Week 8

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Buffalo Bills quarterback Josh Allen passes during warm ups prior to an NFL football game against the Kansas City Chiefs Sunday, Oct. 16, 2022, in Kansas City, Mo. (AP Photo/Ed Zurga)

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The Green Bay Packers and Buffalo Bills will meet in the NFL at Highmark Stadium on Sunday. Kickoff is at 8:20 p.m. ET.

The Bills are betting favorites against the Packers on 10/30/22, with the Over/Under for total points scored set at 48.

This Packers-Bills betting preview, which includes our best bet of the game, is presented by BetMGM and powered by

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Green Bay Packers vs. Buffalo Bills

When and where

  • Date: Sunday, October 30, 2022
  • Time: 8:20 p.m. ET
  • Venue: Highmark Stadium

Odds and lines

  • Point spread: Bills -10.5 (-115), Packers +10.5 (-105)
  • Moneyline: Bills -520, Packers +410
  • Total: Over/Under 48 (-107/-107)

Odds and lines in this article are best available at time of publishing and subject to change.

Packers vs. Bills predictions

Dimers has simulated Sunday's Packers-Bills NFL game 10,000 times using trusted machine learning to predict the most likely outcomes.

According to Dimers' predictive analytics model, the Bills have an 84% chance of beating the Packers at Highmark Stadium.

Dimers also predicts that the bookmakers have got it right and both the Packers and Bills have a 50% chance of covering the spread.

The Over/Under total of 48 points has a 51% chance of going Under.

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Predictions and probabilities are correct at time of publishing but always subject to change.

Best bet for Packers vs. Bills

Our free computer pick for Packers vs. Bills on Sunday is Bills moneyline (-520).

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All betting content in this article is based on world-class modeling and hundreds of different factors to help you make more informed decisions.

Packers-Bills Week 8 player props

A common way to wager on Green Bay vs. Buffalo without necessarily betting on the game's outcome is through prop bets.

The most likely first and anytime touchdown scorers for the Packers and Bills can be seen below.

According to Dimers, Buffalo's Stefon Diggs has the best chance of scoring the first touchdown in Packers vs. Bills.

Dimers gives Diggs a 14.0% chance of scoring the opening TD on Sunday. The Bills WR has a 56.2% probability of scoring an anytime touchdown.

First touchdown scorer probabilities

Green Bay Packers

  • Aaron Jones: 10.5% probability
  • AJ Dillon: 5.7% probability
  • Romeo Doubs: 5.6% probability
  • Robert Tonyan: 4.7% probability
  • Sammy Watkins: 3.1% probability

Buffalo Bills

  • Stefon Diggs: 14.0% probability
  • Gabe Davis: 9.1% probability
  • Devin Singletary: 8.1% probability
  • Josh Allen: 8.0% probability
  • Dawson Knox: 7.3% probability

Anytime touchdown scorer probabilities

Green Bay Packers

  • Aaron Jones: 45.8% probability
  • Romeo Doubs: 27.8% probability
  • AJ Dillon: 26.6% probability
  • Robert Tonyan: 24.0% probability
  • Sammy Watkins: 16.3% probability

Buffalo Bills

  • Stefon Diggs: 56.2% probability
  • Gabe Davis: 40.7% probability
  • Josh Allen: 36.9% probability
  • Devin Singletary: 36.4% probability
  • Dawson Knox: 33.6% probability

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Packers vs. Bills score prediction

Dimers' predicted final score for Green Bay vs. Buffalo at Highmark Stadium has the Bills winning 29-18.

This prediction is based on both teams' average score after 10,000 game simulations.

The NFL Week 8 game between the Packers and Bills on Sunday is scheduled to start at 8:20 p.m. ET at Highmark Stadium.

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