Giving birth at a young age helps protect women from breast cancer. Could a drug mimic that effect?

kA 4=2DDlQ<CE%6IEQm(92E :7 J@F?8 H@>6? 4@F=5 E2<6 2 5CF8 E92E H@F=5 >:>:4 E92E 42?46C\AC6G6?E:?8 67764E @7 7F==\E6C> AC68?2?4Jnk^Am

kA 4=2DDlQ<CE%6IEQmu@I r92D6 r2?46C r6?E6C C6D62C496C y@D6 #FDD@[ ff[ :D :?DA:C65 2?5 5C:G6? 3J E92E 2F524:@FD :562]k^Am

kA 4=2DDlQ<CE%6IEQmq68:??:?8 :? E96 `hf_D[ #FDD@ 2?5 9:D 4=@D6DE 4@==23@C2E@C — 9:D =2E6 H:76[ xC>2 — H@C<65 E@ 564:A96C E96 3:@=@8:42= 32D:D 7@C E96 ?2EFC2= AC@E64E:@? AC@G:565 3J 92G:?8 2 323J 2E 2 J@F?8 286] x? |2C49[ 96 2?5 2? :?E6C?2E:@?2= E62> AF3=:D965 E96 4F=>:?2E:@? @7 E92E H@C<[ 567:?:?8 E96 >@=64F=2C 492?86D[ @C “86?@>:4 D:8?2EFC6[” @7 3C62DED >2EFC65 3J 49:=53:CE9]k^Am

kA 4=2DDlQ<CE%6IEQm#FDD@’D E62> 2=D@ C646?E=J 4@>A=6E65 2 4=:?:42= EC:2= :? H9:49 J@F?8 H@>6? H:E9 2 86?6E:4 AC65:DA@D:E:@? E@ 3C62DE 42?46C E@@< 2 76CE:=:EJ 5CF8 E92E[ :? C2E 6IA6C:>6?ED[ AC6G6?E65 E96 5:D62D6] %96 E62> :D ?@H 2?2=JK:?8 D2>A=6D @7 E96 H@>6?’D 3C62DE E:DDF6 :? 9@A6D @7 7:?5:?8 E96 AC@E64E:G6 86?@>:4 D:8?2EFC6]k^Am

kA 4=2DDlQ<CE%6IEQm#FDD@ H2D 4:C4F>DA64E 2D 96 5:D4FDD65 E96 DEF5J[ H9:49 6?C@==65 bd H@>6? :? q6=8:F> H9@ 42CCJ q#rp`^a 86?6 56764ED]k^Am

kA 4=2DDlQ<CE%6IEQm“(6 2C6 G6CJ ?62C E@ 92G:?8 E96 7:?2= 2?DH6C 2?5 H6 H@CCJ E92E :7 H6 E2=< E@@ >F49[ :E 4@F=5 72== 2A2CE[” 96 D2:5] “qFE E96 :562 :D E@ AC@5F46 E96 D2>6 492?86D 2D AC68?2?4J — H:E9@FE AC68?2?4J]”k^Am

kA 4=2DDlQ<CE%6IEQm|@C6 E92? b__ J62CD 28@[ :? 9:D 72>@FD 3@@< s:D62D6D @7 (@C<6CD[ xE2=:2? A9JD:4:2? q6C?2C5:?@ #2>2KK:?: ?@E65 E92E 3C62DE 42?46C H2D F?FDF2==J 4@>>@? 2>@?8 ?F?D] w6 DA64F=2E65 E92E E96:C 49:=5=6DD?6DD H2D 2 3:8 724E@C]k^Am

kA 4=2DDlQ<CE%6IEQmu=2D9 7@CH2C5 E@ E96 `he_D[ H96? w2CG2C5 &?:G6CD:EJ 6A:56>:@=@8:DE qC:2? |24|29@? =65 2 DEF5J @7 >@C6 E92? `f[___ H@>6? 7C@> 4@F?EC:6D H:E9 9:89[ :?E6C>65:2E6[ 2?5 =@H 3C62DE 42?46C C2E6D] %96 C6DF=ED 4=62C=J D9@H65 E96 :>A@CE2?46 @7 286 2E 7:CDE 3:CE9] (@>6? H9@ 56=:G6C65 367@C6 286 `g D=2D965 E96:C 3C62DE 42?46C C:D< 3J e_T 4@>A2C65 E@ H@>6? H:E9 2 7:CDE 323J 27E6C 286 bd]k^Am

kA 4=2DDlQ<CE%6IEQm%9:D C6AC@5F4E:@?\3C62DE 42?46C =:?< :D 4@>A=6I[ 2?5 :E :D :?E6CH@G6? H:E9 @E96C 724E@CD — DF49 2D 286 2E 7:CDE >6?DECF2E:@? 2?5 2E >6?@A2FD6 — E92E D92A6 2 H@>2?’D =:76E:>6 6IA@DFC6 E@ 6DEC@86?[ 2 9@C>@?6 E92E 7F6=D 3C62DE 42?46C]k^Am

kA 4=2DDlQ<CE%6IEQmr92?8:?8 49:=5362C:?8 A2EE6C?D 2C6 C67=64E65 :? C:D:?8 C2E6D @7 3C62DE 42?46C @G6C E96 =2DE 46?EFCJ] x? (6DE6C? 4@F?EC:6D[ H@>6? 2C6 :?4C62D:?8=J 92G:?8 49:=5C6? =2E6C — @C ?@E 2E 2==] uC@> E96 `hb_D E9C@F89 E96 6?5 @7 E96 a_E9 46?EFCJ[ E96 =:76E:>6 3C62DE 42?46C C:D< :?4C62D65 DE625:=J 2?5 5C2>2E:42==J E@ @?6 :? 6:89E H@>6?] p=E9@F89 :?4:56?46 92D =6G6=65 @77[ :E C@D6 3J >@C6 E92? c_T 36EH66? `hfb 2?5 `hhg]k^Am

kA 4=2DDlQ<CE%6IEQmx? E96 &]$][ E2>@I:76? 2?5 C2=@I:76?6 92G6 366? 2AAC@G65 E@ =@H6C 3C62DE 42?46C C:D<[ 3FE E96D6 5CF8D H@C< 3J :?E6C76C:?8 H:E9 6DEC@86? — ?@E 3J >2EFC:?8 E96 3C62DE E:DDF6 — 2?5 4@>6 H:E9 F?A=62D2?E[ @442D:@?2==J 52?86C@FD[ D:56 67764ED]k^Am

kA 4=2DDlQ<CE%6IEQm#FDD@ 2?5 9:D H:76[ H9@ H6C6 3@C? :? pC86?E:?2[ 6>:8C2E65 E@ E96 &]$] :? `hf` 2?5 =2F?4965 E96:C 3C62DE 42?46C C6D62C49 =23] qJ DEF5J:?8 46==D 2?5 6IA6C:>6?E2= 2?:>2=D[ E96J AC@G:565 5:C64E 6G:56?46 @7 H92E @E96C C6D62C496CD E96@C:K65i uF==\E6C> AC68?2?4J EC:886CD E96 DF556? 8C@HE9 @7 >:=< 5F4ED[ =625:?8 E@ >2EFC2E:@? @7 E96 >2>>2CJ 8=2?5] (96? E9:D >2EFC2E:@? 92AA6?D 2E 2 J@F?8 286[ :E C65F46D E96 492?46 E92E 86?6E:4 52>286 H:== 244F>F=2E6 :? E96 46==D 2?5 36 4@A:65 H96? E96J 5:G:56[ D665:?8 2 >2=:8?2?4J]k^Am

kA 4=2DDlQ<CE%6IEQm#FDD@’D E62> :56?E:7:65 cb 86?6D E92E 5C:G6 3C62DE >2EFC2E:@?[ :?4=F5:?8 86?6D E92E >2<6 E96 46==D’ ?F4=62C s}p 8@ 7C@> 36:?8 =@@D6=J 4@:=65 E@ 36:?8 E:89E=J 4@:=65 :? DECF4EFC6D 42==65 49C@>2E:?] %9:D “49C@>2E:? C6>@56=:?8” D9:6=5D E96 s}p 7C@> 86?6E:4 52>286]k^Am

kA 4=2DDlQ<CE%6IEQm“(92E AC68?2?4J 5@6D :D >2<6 E96 4@:=:?8 >@C6 4@>A24E[” #FDD@ D2:5]k^Am

kA 4=2DDlQ<CE%6IEQmtG6? 367@C6 E96D6 >@=64F=2C >6492?:D>D 3642>6 4@>A=6E6=J 4=62C[ E96 #FDD@ =23 AF3=:D965 DEF5:6D D9@H:?8 E92E 9F>2? 49@C:@?:4 8@?25@EC@A:? W9rvX — 2 9@C>@?6 >256 3J E96 A=246?E2 E@ >2:?E2:? 2 AC68?2?4J — 4@F=5 36 FD65 E@ AC6G6?E 3C62DE 42?46C :? C2ED =2E6C 6IA@D65 E@ 2 42?46C\42FD:?8 286?E]k^Am

kA 4=2DDlQ<CE%6IEQmp7E6C xC>2 #FDD@ 5:65 @7 @G2C:2? 42?46C :? a_`b[ 96C 9FD32?5 =@DE 9@A6 @7 EC2?D=2E:?8 E96 2?:>2= 7:?5:?8D E@ H@>6?] u:?5:?8 7F?5:?8 7@C 2 4=:?:42= DEF5J[ @G6C4@>:?8 6E9:42= 4@?46C?D[ 2?5 C64CF:E:?8 962=E9J H@>6? H:==:?8 E@ F?56C8@ 3C62DE 3:@AD:6D 367@C6 2?5 27E6C EC62E>6?E[ D66>65 E@@ 52F?E:?8]k^Am

kA 4=2DDlQ<CE%6IEQm%96?[ :? a_`c[ #FDD@ 82G6 2 =64EFC6 2E 2 D4:6?E:7:4 4@?76C6?46 :? q6=8:F>] w6 H2D 2AAC@24965 3J w6C>2? s6AJA6C6[ 2? @3DE6EC:4:2?\8J?64@=@8:DE 2E v96?E &?:G6CD:EJ w@DA:E2=]k^Am

kA 4=2DDlQ<CE%6IEQm“w6 D2:5 E@ >6[ ‘x H@F=5 =:<6 E@ ECJ E@ 5@ E96 EC:2= 3642FD6 x 92G6 E96 A@AF=2E:@?’” @7 J@F?8 H@>6? 2E 9:89 C:D< @7 3C62DE 42?46C[ #FDD@ C642==65]k^Am

kA 4=2DDlQ<CE%6IEQm%96 bd A2CE:4:A2?ED[ 49:=5=6DD H@>6? 286D `g E@ b_ H9@ 42CCJ q#rp`^a >FE2E:@?D[ C646:G65 :?;64E:@?D @7 ~G:EC6==6 — 2 DJ?E96E:4 9rv FD65 :? 76CE:=:EJ EC62E>6?E E@ :?5F46 @GF=2E:@? — E9C66 E:>6D 2 H66< 7@C E9C66 >@?E9D] %96J H6C6 4=@D6=J >@?:E@C65 7@C AC68?2?4J DJ>AE@>D[ @G2C:2? @G6CDE:>F=2E:@?[ 2?5 @E96C A@E6?E:2= AC@3=6>D[ 3FE ?@?6 56G6=@A65[ s6AJA6C6 D2:5 :? 2 AC6D6?E2E:@?]k^Am

kA 4=2DDlQ<CE%6IEQm%96 EC:2= :D @?=J 2 DE6A E@H2C5 AC@G:?8 E92E AC68?2?4J\=:<6 AC@E64E:@? 42? 36 2CE:7:4:2==J EC:886C65[ #FDD@ D2:5] tG6? :7 9rv 492?86D E96 H@>6?’D 86?@>:4 AC@7:=6D[ E96J H@F=5 92G6 E@ 36 7@==@H65 7@C J62CD E@ D66 H96E96C E92E 24EF2==J AC6G6?E65 3C62DE 42?46C] p?5 =2C86 EC:2=D H@F=5 36 ?66565 E@ D9@H E96 5CF8 H@C<D :? H@>6? H:E9@FE q#rp >FE2E:@?D]k^Am

kA 4=2DDlQ<CE%6IEQm$E:==[ 96 :D 9@A67F= E92E 9:D =:76’D H@C< H:== F=E:>2E6=J 6>A@H6C H@>6? E@ AC@E64E E96:C 962=E9 :? 2 ?6H H2J]k^Am

kA 4=2DDlQ<CE%6IEQm“x H@F=5 =:<6 E9:D E@ 36 >J =6824J[” 96 D2:5] “x 2> ff] x 5@?’E <?@H 9@H =@?8 x H:== <66A 8@:?8] qFE E96 :562 E92E H6 42? 4@?76C AC@E64E:@? H:E9@FE E96 ?646DD:EJ @7 49:=53:CE9 :D 6I4:E:?8] p== H6 42? 5@ :D =62C? 7C@> ?2EFC6]”k^Am